Fexinidazole in Human African Trypanosomiasis Due to T.b. Gambiense at Any Stage

Inclusion Criteria: * Male or female patient, including breastfeeding or pregnant women in the second or third trimester. * ≥ 6 years of age. * ≥ 20 kg body weight. * Signed Informed Consent Form and Assent Form for patients less than 18 years of age * Trypanosomes detected in any body fluid. * Physically able to ingest at least one solid meal per day. * Able to take oral medication. * Karnofsky Performance Status \> 40%. * Able to comply with the schedule of follow-up visits and with the study constraints. * Easily reachable during the out-patient follow-up period. * Willing to undergo lumbar punctures. Exclusion Criteria: * Active clinically relevant medical conditions other than HAT that, in the Investigator's opinion, could jeopardize patient safety or interfere with participation in the study, including but not limited to significant liver or cardiovascular diseases, human immunodeficiency virus (HIV) infection, central nervous system (CNS) trauma or seizure disorders, coma or altered consciousness not related to HAT. * Severe renal or hepatic impairment defined as: elevated creatinine at \> 3 times the upper limit of normal (ULN); elevated alanine aminotranferase (ALT), aspartate aminotransferase (AST), or bilirubin at \> 3 ULN * Severely deteriorated general condition, such as cardiovascular shock, respiratory distress or terminal illness. * Any condition (except symptoms of HAT) that compromises ability to communicate with the Investigator as required for complet…