RecruitingNot Applicable

Unequal Placental Sharing in Monochorionic Diamniotic Twins: an Observational Study

Belgium393 participantsStarted 2016-04

Plain-language summary

This is an observational study in 3 cohorts of monochorionic diamniotic (MCDA) twins. The aim of the study is to assess whether unequal placental sharing can be predicted in pregnancy and whether it is predictive of pregnancy outcome.

Who can participate

Age range18 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * MCDA cohort * Ongoing monochorionic diamniotic twin pregnancy between 11 and 14 weeks, as determined by the crown rump length of the larger twin in spontaneous conceptions and by the date of insemination or embryonic age at replacement in pregnancies resulting from subfertility treatment * Women aged 18 years or more, who are able to consent * Written informed consent to participate in this study, forms being approved by the Ethical Committees * TTTS cohort * Monochorionic diamniotic twin pregnancy, with gestational age defined in the first trimester as mentioned above * Complicated by TTTS according to the definition used in the Quintero staging of TTTS (DVP of donor \< 2 cm and DVP of receptor \> 8 cm before 20 weeks or \> 10 cm after 20 weeks * Undergoing laser surgery for TTTS * Women aged 18 years or more, who are able to consent * Written informed consent to participate in this study, forms being approved by the Ethical Committees * sIUGR cohort * Monochorionic diamniotic twin pregnancy, with gestational age defined in the first trimester as mentioned above * Complicated by sIUGR defined as a discordance in EFW of ≥ 20%, with the percentage of discordance being calculated as (EFW larger twin - EFW smaller twin)/EFW larger twin x 100. * Women aged 18 years or more, who are able to consent * Written informed consent to participate in this study, forms being approved by the Ethical Committees Exclusion Criteria: * Age \< …

What they're measuring

MCDA cohort: the association between unequal sharing and risk of fetal or neonatal loss (assessed by review of obstetric and pediatric records)

Timeframe: 2 weeks after expected date of birth

TTTS cohort: the association between unequal sharing and intrauterine fetal death (assessed by review of obstetric records)

Timeframe: 2 weeks after expected date of birth

sIUGR cohort: the association between unequal sharing and risk of fetal or neonatal loss and birth prior to 34 weeks (assessed by review of obstetric and pediatric records)

Timeframe: 2 weeks after expected date of birth

Trial details

NCT IDNCT03024918

SponsorUniversitaire Ziekenhuizen KU Leuven

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2025-06

Contact for this trial

Isabel Couck

+32 16 34 22 94 isabel.couck@uzleuven.be

View on ClinicalTrials.gov More Monochorionic Twins trials

Who can participate

Age range18 Years

SexFEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

MCDA cohort: the association between unequal sharing and risk of fetal or neonatal loss (assessed by review of obstetric and pediatric records)

Timeframe: 2 weeks after expected date of birth

TTTS cohort: the association between unequal sharing and intrauterine fetal death (assessed by review of obstetric records)

Timeframe: 2 weeks after expected date of birth

sIUGR cohort: the association between unequal sharing and risk of fetal or neonatal loss and birth prior to 34 weeks (assessed by review of obstetric and pediatric records)

Timeframe: 2 weeks after expected date of birth