CompletedNot Applicable

VCRC Longitudinal Protocol for Aortitis

United States16 participantsStarted 2017-12-04

Plain-language summary

The term 'aortitis' refers to inflammation of the aorta. Aortitis is known to occur in a variety of vasculitides and connective tissue diseases, such as giant cell arteritis (GCA), Takayasu arteritis (TAK), rheumatoid arthritis, and spondyloarthropathies, among others. This study will establish a longitudinal cohort for these diseases.

Who can participate

Age range5 Years

SexALL

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Inclusion criteria

✓. Previous or current microscopic evidence of aortitis (active or healed) on surgical specimen obtained during aortic resection
✓. Previous or current radiographic aortitis that could include circumferential aortic wall thickening of at least 3mm on CT or MRI or increased PET FDG uptake in the aorta at values equal to or greater than the liver, in absence of an alternative explanation for the radiographic findings.

Exclusion criteria

✕. Subjects already enrolled in one of the other VCRC longitudinal cohorts: 5502, 5503, 5504, 5505, and 5506.
✕. Inability of participants (or their guardians in the case of children) to give informed consent and to sign the consent form.

What they're measuring

Phenotypic correlates of genotype

Timeframe: 5 years

Trial details

NCT IDNCT03022331

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-09-01

View on ClinicalTrials.gov More Aortitis trials