Atherosclerosis, Immune Mediated Inflammation and Hypoestrogenemia in Young Women

Inclusion Criteria: For premenopausal Hypo E and normal control women, inclusions include: * Premenopausal currently not on hormone therapy, * English speaking (for the purposes of complete psychosocial assessment) * able to give informed consent * a gynecological age (age since menarche) \> 10 and \< 25 years, and chronological age \> 18 years * Within 90-110% of ideal body weight as determined by the 1983 Metropolitan Height and weight table for women * All participants with hypothalamic amenorrhea will be diagnosed based on exclusion of other etiologies for their amenorrhea, including pregnancy, thyroid dysfunction, hyperprolactinemia, premature ovarian insufficiency, and polycystic ovary disease For recently menopausal women inclusions include: * Follicle stimulating hormones (FSH) \>30 and 12 months of amenorrhea, within 3 years of final menstrual period with natural menopausal not on hormone therapy * English speaking * Able to give informed consent * Within 90-110% of ideal body weight Exclusion Criteria: For premenopausal Hypo E and normal control women exclusions include: * Smoking * Hypertension * Hyperlipidemia * Diabetes * Medications including psychotropic or illicit drugs, medical, neurological * Ophthalmologic disease except acuity problems * Major Axis I disorder other than depression * Pregnancy in the last 12 months and/or lactating in the last 6 months * Current use of hormone contraceptive or any estrogen or progestin therapy For HypoE women, exclu…