This study aims to better characterise B cell phenotype and functional abnormalities in kidney transplant patients producing donor specific antibody (DSA) and in those with chronic antibody mediated rejection (cAMR) and to search for a predictive tool (biomarker). The functional analysis will help to better understand B cell-dependant mechanisms implied in T cell proliferation and better target future treatments.
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Evaluation of the ratio (percentage and absolute values) of mature LB subpopulations (LBm1 to LBm5) and of memory LB by specific labellings
Timeframe: At the inclusion day
Evaluation of the proliferation of freshly isolated cells T in presence of autologous B cells
Timeframe: At the inclusion day
Evaluation of the proliferation of T cells in a heterologous test
Timeframe: At the inclusion day
cytokine analysis(IL10, alpha-Tumor Necrosis FActor, gamma-Interferon dosing)
Timeframe: At the inclusion day