Prediabetes is defined as an intermediate metabolic state that leads to the development of type 2 diabetes mellitus (DM2) and the prehypertension is a category assigned to identify patients who are at risk of developing hypertension (AH), in both pathologies the abnormalities in the variation of blood pressure (BP) has been related to organ damage, its evaluation is performed by ambulatory blood pressure monitoring (ABPM). Dapagliflozin is a selective and reversible inhibitor of the sodium-glucose co-transporter type 2 (SGLT-2), which reduces renal reabsorption of glucose and promotes the excretion of glucose through the urine, in the way that glucose blood. Another reported effects is the decrease on BP, so it would be interesting to evaluate this effects in patients with prediabetes and prehypertension, as a potential therapy to treat disorders and to prevent progression to DM2 and Hypertension, respectively. The aim of this study is to evaluate the effect of Dapagliflozin on variability of blood pressure in patients with prediabetes and prehypertension without pharmacological treatment. The investigators hypothesis is that the administration of dapagliflozin decreases variability of blood pressure in patients with prediabetes and prehypertension without pharmacological treatment.
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24-hours Systolic Blood Pressure at Week 12
Timeframe: Week 12
24-hours Diastolic Blood Pressure at Week 12
Timeframe: Week 12
Daytime Systolic Blood Pressure at Week 12
Timeframe: Week 12
Daytime Diastolic Blood Pressure at Week 12
Timeframe: Week 12
Nighttime Systolic Blood Pressure at Week 12
Timeframe: Week 12
Nighttime Diastolic Blood Pressure at Week 12
Timeframe: Week 12
Systolic Blood Pressure Weighted Standard Deviation at Week 12
Timeframe: Week 12
Diastolic Blood Pressure Weighted Standard Deviation at Week 12
Timeframe: Week 12
Coefficient of Variation of 24-hours, Systolic Blood Pressure at Week 12
Timeframe: Week 12
Coefficient of Variation of 24-hours, Diastolic Blood Pressure at Week 12
Timeframe: Week 12
Coefficient of Variation Daytime, Systolic Blood Pressure at Week 12
Timeframe: Week 12
Coefficient of Variation Daytime, Diastolic Blood Pressure at Week 12
Timeframe: Week 12
Coefficient of Variation Nighttime, Systolic Blood Pressure at Week 12
Timeframe: Week 12
Coefficient of Variation Nighttime, Diastolic Blood Pressure at Week 12
Timeframe: Week 12
Average Real Variability of Systolic Blood Pressure at Week 12
Timeframe: Week 12
Average Real Variability of Diastolic Blood Pressure at Week 12
Timeframe: Week 12
Number of Participants With a Nondipper Circadian Blood Pressure Pattern at Week 12
Timeframe: Week 12
Number of Participants With a Dipper Circadian Blood Pressure Pattern at Week 12
Timeframe: Week 12
Number of Participants With a Dipper Reverse Circadian Blood Pattern at Week 12
Timeframe: Week 12