CompletedPhase 2/3

Ketamine Efficacy for Acute Severe Bronchospasm in ICU: MACANUDO Trial

Brazil45 participantsStarted 2015-06-04

Plain-language summary

Despite few scientific evidence that could support the use of ketamine in adult patients undergoing acute bronchospasm requiring mechanical ventilation (MV), ketamine is largely employed in this setting. The aim of this study is therefore assess more definitively the real benefit of using ketamine in patients with severe bronchospasm, requiring ICU stay and need for MV in order to establish or refute the use of this drug as "standard therapy" in these cases.

Who can participate

Age range18 Years

SexMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * patients with acute exacerbation of COPD or status asthmaticus, undergoing controlled mechanical ventilation * acute bronchospasm, defined as airway resistance value (Rsr max) greater than 12, use of inhaled therapy with bronchodilators and systemic corticosteroids * patients requiring the use of continuous intravenous sedation for optimization of ventilation Exclusion Criteria: * contraindication or history of previous adverse events with the use of the studied drugs * other diagnostic potential Rsr increase of not causing bronchospasm (bronchial obstruction, acute respiratory distress syndrome adult, pulmonary fibrosis)

What they're measuring

bronchospasm improvement

Timeframe: 3 hours post beginning of drug infusion

Trial details

NCT IDNCT03000413

SponsorHospital Nossa Senhora da Conceicao

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-06-16

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