UnknownPhase 1

Multi-Target Pallidal and Thalamic Deep Brain Stimulation for Hemi-Dystonia

Canada4 participantsStarted 2015-01

Plain-language summary

Dystonia is increasingly being considered as a multi-nodal network disorder involving both basal ganglia and cerebellar dysfunction. The aim of this study is to determine if "Multi-Target" Thalamic and Pallidal Deep Brain Stimulation improves hemi-dystonia patients who are receiving inadequate therapy from GPi DBS.

Who can participate

Age range18 Years – 65 Years

SexALL

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Inclusion criteria

✓. Diagnosed with hemi-dystonia secondary to stroke
✓. Candidate for GPi DBS
✓. Able to provide informed consent

Exclusion criteria

✕. History of intracranial pathology (such as multiple sclerosis, tumors, or aneurysms) that may account for dystonia or essential tremor.
✕. History or evidence of ongoing psychiatric or neurodegenerative disorders (such as Parkinson's disease, Alzheimer's disease).
✕. Incompetent adults or those unable to communicate.

What they're measuring

Burke Fahn Marsden Disability Rating Scale (BFMDRS)

Timeframe: 3 months

SF-36 Quality of Life Scale

Timeframe: 3 months

Adverse effects of Vim or Vim + GPi Neuromodulation

Timeframe: 3 months

Trial details

NCT IDNCT02982304

SponsorUniversity of British Columbia

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2021-12

Contact for this trial

Chris Honey, MD,DPhil,FRCSC

604-875-5894 chris.honey@telus.net

View on ClinicalTrials.gov More Dystonia trials