Randomized Evaluation of BST-CarGel Versus Microfracture Alone On Recovery From Distal Femoral Cartilage Lesions

Inclusion Criteria: * requires cartilage repair treatment due to distal femoral cartilage lesion * is 18-55 years of age at the time of surgery * has single, focal cartilage lesion on one of the femoral condyles * has symptomatic cartilage lesion that has failed conservative management * has a single lesion classified as focal, full-thickness grade 3 or 4 according to the ICRS (3A, 3B, 3C, 3D and 4A) * an area of lesion between 1.5-3 cm2 after debridement * has a stable knee (\<5-mm side-to-side difference on Lachman and varus and valgus stress testing and grade 0 or 1 on the pivot-shift test) and an intact meniscal rim * is willing and able to participate in required follow-up visits at the investigational site and to complete study procedures and questionnaires and recommended physiotherapy regimen * has agreed to discontinue the use of all knee pain medication 3 days before the pre-treatment visit and the post-treatment follow-up visits at 3, 6, 9, 12, and 24 months * has consented to participating in the study by signing the IRB/EC approved informed consent form * no deep osteochondral defect ( \< 5 mm bone loss) Exclusion Criteria: * has multiple lesions or kissing (opposing) lesion(s) greater than GII * has clinically relevant compartment malalignment (\>5°) * has bone cyst(s) associated with, or adjacent to, the index lesion * has Osteochondritis Dissecans with bone or bone-cartilage fragment in place * has had ligament treatments in the index knee within the previo…