Oral Iron for Erythropoietic Protoporphyrias

Inclusion Criteria: * Enrollment in the Longitudinal Study of the Porphyrias * Male or female age ≥18 years * History of nonblistering cutaneous photosensitivity * Biochemical findings - A marked increase in erythrocyte protoporphyrin (total erythrocyte protoporphyrin \>400 ug/dL) with a predominance of metal-free protoporphyrin * Serum ferritin ≤30 ng/mL at baseline * Able to tolerate oral iron Exclusion Criteria: * History of liver or bone marrow transplant or clinically significant liver dysfunction as determined by the investigator * Known or suspected allergy to oral iron based on patient report * Clinical evidence of active and ongoing GI bleeding * Use of any other clinical or experimental therapy in the past 3 months * Individuals with elevations of porphyrins in plasma or erythrocytes due to other diseases (i.e. secondary porphyrinemia) such as liver and bone marrow diseases * Patients with any clinically significant comorbid conditions, which in the opinion of the investigator, precludes participation