TerminatedPhase 2

Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest

Stopped: Study stopped early after consultation with DSMB

United States41 participantsStarted 2017-05-01

Plain-language summary

This study is to evaluate whether thiamine can increase oxygen consumption and lower lactate in patients who initially survive an in-hospital cardiac arrest. Patients who are successfully resuscitated after an in-hospital cardiac arrest and who are on mechanical ventilation in the intensive care unit will be enrolled, and will get either thiamine or placebo. Their oxygen consumption and lactate will be measured at serial time points and compared between groups. The investigators' hypothesis is that thiamine will help restore the body's ability to metabolize oxygen normally (aerobic metabolism), leading to an increase in oxygen consumption and a decrease in lactate.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patient (age \> 18 years) * Cardiac arrest occurring while admitted to the hospital, with sustained (\>20 minutes) return of spontaneous circulation (ROSC) * Mechanically ventilated at the time of enrollment * Within 12 hours of cardiac arrest event Exclusion Criteria: * Clinical indication for thiamine administration (alcoholism, known or highly suspected deficiency) or treatment with thiamine beyond the amount found in a standard multivitamin within the last 10 days * Comfort measures only or anticipated withdrawal of support within 24 hours * Severe agitation * Protected populations (pregnant women, prisoners)

What they're measuring

Lactate

Timeframe: 2 days

Trial details

NCT IDNCT02974257

SponsorBeth Israel Deaconess Medical Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-02-07

Results submitted2023-05-01

View on ClinicalTrials.gov More Cardiac Arrest trials