Prognostic Analysis of Concurrent Chemoradiotherapy With/Without Adjuvant Chemotherapy for Locally Advanced NPC Patients

Inclusion Criteria: * Newly histologic diagnosis of nasopharyngeal carcinoma(WHO II/III) * Clinical stage III\~IVb(UICC/AJCC 7th) * No distant metastasis * Karnofsky Performance Status Scale≥70 * WBC count ≥ 4×109/L, neutrophil differential count≥ 1.5×109/L, Hemoglobin ≥ 90g/L, platelet count ≥ 100×109/L * ALT or AST ≤2.5×ULN,bilirubin ≤2.5×ULN, Serum creatinine ≤1.5×ULN or Serum creatinine clearance≥60ml/min * Sign the informed consent. Exclusion Criteria: * Angle of sexual squamous cell carcinomas and basal cell layout, squamous cell carcinomas * Younger than 18 years old or older than 70 years old * Are receiving other drugs treanment * kidney disease * Have suffered from other tumor or now suffering from other tumor * Have recieved chemotherapy or radiotherapy * Pregnancy or lactation * unstable heart disease need timely treatment * Severe cerebrovascular disease/canker/psychosis/uncontrolled diabetes