Mindful Self-Regulation fMRI Pilot Study

Inclusion Criteria: * Adults 21-60 years old enrolled for participation in the MINDFUL-PC study. * During baseline visit, patient has a history of either major depressive disorder, dysthymia, or generalized anxiety disorder, OR has current mild to moderate symptoms of depression (score range of 10-28 on DASS-21 Depression subscale) or anxiety (score \>7 on DASS-21 anxiety subscale). * Participant does not have a substance use disorder nor intoxication at the time of scanning. Participants must report no more than infrequent recreational cannabis use (i.e., no more than two times a month) and must report capacity for abstinence from both cannabis and ethyl alcohol for the 72 hours prior to the scan. * Normal or corrected-to-normal vision, and correction must be with contact lenses. * Right-handed as defined by Edinburgh Handedness Inventory. Exclusion Criteria: * Current severe panic disorder, active severe PTSD symptoms, or psychosis. * Current suicidality OR severe depression as evidenced by a score of 28 or higher on the DASS-21 Depression subscale. * Standard direct exclusion criteria for undergoing magnetic resonance imaging (MRI) procedures for research purposes (safety standards), i.e., Meniere's disease, epilepsy, strong claustrophobia, currently pregnant or breastfeeding or planning to conceive or breastfeed during the study, cardiac pacemaker, prosthetic heart valve, neurostimulator, implanted pumps, non-MR-compatible implants or devices. * A history of neurologic…