CompletedEarly Phase 1

Effect of Enamel Matrix Proteins on Clinical Attachment Level and Alveolar Bone in Periodontal Maintenance Patients

United States50 participantsStarted 2017-02-01

Plain-language summary

The purpose of the study is to determine the effect of enamel matrix protein derivative on an inflamed, periodontal-involved tooth. The hypothesis to be studied is that enamel matrix derivative protein with increase the clinical attachment level is localized sites of advanced periodontal disease.

Who can participate

SexALL

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Inclusion Criteria: * diagnosis of chronic advanced adult periodontitis * one quadrant with at least one 6-9 mm interproximal pocket * overall good systemic health * willingness to sign consent form Exclusion Criteria: * systemic diseases which significantly impact periodontal inflammation and bone turnover (e.g. rheumatoid arthritis) * taking drugs which significantly impact periodontal inflammation and bone turnover * surgical periodontal therapy within the past year * pregnant or breast-feeding females

What they're measuring

Clinical Attachment Levels

Timeframe: 12 months

Trial details

NCT IDNCT02972788

SponsorUniversity of Nebraska

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-09-20

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