Expedited Laser Interstitial Thermal Therapy + Chemoradiation For Newly Diagnosed High Grade Gliomas

Inclusion Criteria: * Subjects must have suspected high grade glioma by MRI * Subjects must have received no prior therapies for this disease. * Patients must be considered appropriate candidates for LITT. * Karnofsky Performance status ≥ 60% * Subjects must have normal organ and marrow function as defined below. Measures of function must be within 14 days prior to registration. * Absolute neutrophil count (ANC) ≥ 1500 cells/mm3, platelets ≥ 100,000 cells/mm3, hemoglobin ≥ 10.0 g/dl. Use of transfusion or other intervention to achieve this hemoglobin level is acceptable. * Blood urea nitrogen ≤ 30mg/dl and creatinine ≤ 1.7 mg/dl * Bilirubin ≤ 2.0 mg/dl, Aspartate aminotransferase/ Alanine aminotransferase (AST/ALT) ≤ 3x upper limit of normal * Electrocardiogram without evidence of acute cardiac ischemia * Prothrombin time/international normalized ratio (PT INR) \<1.4 * Women of childbearing potential and male participants must practice adequate contraception. * For women of childbearing age, negative pregnancy test within 14 days prior to registration * Subjects must have the ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Participants not eligible to obtain MRI with and without contrast * Recurrent High grade gliomas (HGG) * Cerebral edema, grade 3 or greater prior to surgery * Post-operative complications including significant neurological decline or hemorrhage that causes a drop in KPS to less than …