CompletedPhase 2/3

Two Different Antibiotic Agents to Treat Generalized Aggressive Periodontitis

Brazil46 participantsStarted 2015-03

Plain-language summary

The aim of this study is to assess the clinical outcomes of full-mouth ultrasonic debridement combined with clarithromycin or amoxicillin + metronidazole association for the treatment of generalized aggressive periodontitis (GAgP).

Who can participate

Age range18 Years – 35 Years

SexALL

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Inclusion criteria

✓. diagnosis of GAgP (AAP, 1999);
✓. presence of ≥20 teeth;
✓. presence of ≥ 6 sites presenting PD ≥ 5mm with bleeding on probing (BOP) and ≥2 sites with PD ≥7mm (including incisors and first molars, in addition to other two non-contiguous teeth);
✓. good general health;
✓. ≤ 35 years old; and
✓. agree to participate in the study and sign a written informed consent. All subjects will be individually informed about the objectives, probable risks and benefits of the protocol treatment (according to Resolution nº196 of October 1996 and to the Professional Code of Dental Ethics - 179/93).

Exclusion criteria

✕. pregnancy or lactating;
✕. suffer from any systemic disease (e.g. cardiovascular disorders, diabetes, blood dyscrasias, immunodeficiency, etc) which could alter the course of periodontal disease;
✕. took antimicrobials in the previous 6 months;
✕. taking long-term anti-inflammatory drugs;
✕. previous periodontal treatment within the last 12 months;
✕. smokers.

What they're measuring

Change in Clinical Attachment Level (CAL)

Timeframe: Baseline, 3 and 6 months

Trial details

NCT IDNCT02969928

SponsorUniversidade Estadual Paulista Júlio de Mesquita Filho

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-12

Results submitted2020-05-04

View on ClinicalTrials.gov More Aggressive Periodontitis trials