Gadobutrol Versus Gadopentetate Dimeglumine or Gadobenate Dimeglumine Before DCE-MRI in Diagnosing Patients With Multiple Sclerosis, Grade II-IV Glioma, or Brain Metastases

Inclusion Criteria: * Confirmed diagnosis of multiple sclerosis, known or suspected diagnosis of glioma, or known or suspected diagnosis of cerebral metastasis * Scheduled or to be scheduled for a follow-up MRI per standard of care for their disease * Minimum permitted time intervals from prior treatments are 6 weeks for intracranial surgery * Adequate renal function (serum creatinine =\< 1.5 mg/dL) * Subject must sign a study-specific informed consent Exclusion Criteria: * Medically unstable * Renal impairment (glomerular filtration rate \[GFR\] \< 60 mL/min/1.73m\^2) or history of existing nephrogenic systemic fibrosis (NSF) * Cardiac pacemaker * A serious concurrent infection, illness, or medical condition * Subjects with any surgical clip, external clips, or any other ferromagnetic device, that is contraindicated for use in MRI * Subject is claustrophobic and cannot cooperate for the MRI * Females who are pregnant or nursing * Any other condition that would compromise the scan with reasonable safety