European Novel Motorized Spiral Endoscopy Trial

Inclusion Criteria: * Overt obscure gastrointestinal bleeding or obscure gastrointestinal bleeding or indeterminate iron-deficiency anaemia and positive videocapsule endoscopy (VCE) or negative VCE in patients who have ongoing bleeding shown by overt bleeding or continued need for blood transfusions * Abdominal pain or chronic diarrhoea with positive findings of small bowel imaging examinations * Noncontributory ileocolonoscopy and suspicion of Crohn's disease on small-bowel cross-sectional imaging modalities or small-bowel capsule endoscopy * Further evaluation of known Crohn's disease or therapeutic indications in Crohn's disease * Imaging tests suspicious for small-bowel tumour * Large polyps (\>10-15mm) discovered by radiological examination or small-bowel capsule endoscopy in patients with Peutz-Jeghers syndrome * Nonresponsive or refractory coeliac disease Exclusion Criteria: * Age under 18 years * Health status American Society of Anesthesiologists classification (ASA) 4 * Pregnancy * Coagulopathy (INR≥2.0, Platelets \< 70/nl) * Taking anti-platelet agents or anticoagulants (other than aspirin) within last 7 days * Any medical contraindication to standard enteroscopy * Presence of any intraluminal or extraluminal foreign body in the abdominal cavity * Any prior gastric, small bowel or colonic surgery, or implantable devices in these locations (cardiac pacemakers and non-abdominal implants are acceptable) * Known or suspected bowel obstruction or stenosis or history …