UnknownNot Applicable

Longitudinal Early Epilepsy Study

Netherlands60 participantsStarted 2016-09

Plain-language summary

This longitudinal study will focus on the cognitive and brain development of children with absence epilepsy. In addition, the investigators aim to identify prognostic factors for cognitive deterioration and/or poor seizure control in these children.

Who can participate

Age range6 Years – 12 Years

SexALL

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Inclusion criteria

✓. Primarily presented with daily occurring episodes of brief loss of consciousness (absences) in an otherwise normal child in the previous 2 years.
✓. An EEG showing 3 Hz (2.5-4.5 Hz) generalized rhythmic spike-and-wave complexes with a discharge duration of at least 3 seconds on a present or former EEG(58).
✓. Early absence epilepsy , defined as a confirmed diagnosis or seizures within 2 years.
✓. Aged 6-12 years
✓. Permitted accompanying factors:

What they're measuring

Change of multimodal MRI parameters on brain connectivity

Timeframe: Baseline; first year; second year

Change of cognition measured by a battery of neuropsychological tests

Timeframe: Baseline; first year; second year

Time in months since start of medication till seizure control is attained, as assessed by anamnesis and a confirmatory routine-EEG.

Timeframe: Within 2 years

Trial details

NCT IDNCT02954107

SponsorMaastricht University Medical Center

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2019-09

Contact for this trial

Eric LA Fonseca Wald, MD

+31 (0)43 387 65 84 LEES.studie.kinderneurologie@mumc.nl

View on ClinicalTrials.gov More Absence Epilepsy trials