Screening With Whole Body MRI For Detection Of Primary Tumors In Children And Adults With Li-Fraumeni Syndrome (LFS) And Other Cancer Predisposition Syndromes

Inclusion Criteria: * Adults * Individuals greater than or equal to 18 years of age. * Individuals with "Li Fraumeni Syndrome" defined as one of the following: * Carriers of a germline p53 mutation * Members of families meeting classic LFS criteria by family history without an identifiable p53 mutation * Obligate carrier by pedigree (these individuals can be offered testing but are still eligible if they defer). The following examples describe "obligate carriers by pedigree." * A child of a parent with known p53 mutation that is diagnosed with cancer * An individual with a sibling and a child who are p53 positive -OR- * Individuals with an inherited cancer predisposition syndrome as defined by one of the following: * Hereditary Retinoblastoma with a germline Rb mutation * Diagnosis of Hereditary Paraganglioma/Pheochromocytoma Syndrome with a germline SDH mutation * Diagnosis of Multiple Endocrine Neoplasia, Type 1 or 2, with a germline MEN mutation * New diagnosis of opsoclonus-myoclonus with a negative cancer work-up upon presentation of symptoms * Familial Neuroblastoma with a germline ALK mutation * Rapid-onset Obesity with Hypothalamic dysfunction, Hypoventilation and Autonomic Dysregulation (ROHHAD syndrome) or Congenital central hypoventilation syndrome (CCHS) with or without a germline PHOX 2B mutation * Von Hippel-Lindau with a VHL mutation * Women with an abnormal cell-free DNA test (i.e. a non-invasive prenatal test (NIPT) to detect chromoso…