CompletedPhase 2

A Promising Tool for Predicting Consciousness Evolution in Prolonged Disorders of Consciousness

China36 participantsStarted 2017-12-01

Plain-language summary

The research contains two parts. Part 1: To explore whether EEG responses to zolpidem can assess consciousness circuit integrity and predict the evolution of consciousness in patients with prolonged disorders of consciousness; Part 2: To explore if quantitative EEG reactivity might predict the prognosis of disorders of consciousness.

Who can participate

Age range18 Years

SexALL

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Inclusion Criteria: * presence of unresponsive wakefulness syndrome (UWS) or minimally conscious state (MCS) on admission; * time since onset \> 4 weeks; * no history of neurodegenerative or psychiatric diseases. Exclusion Criteria: * allergic to zolpidem; * currently receiving zolpidem or related benzodiazepines; * diagnosed with seizure or status epilepticus.

What they're measuring

The Coma Recovery Scale-Revised

Timeframe: Six months after enrollment

Trial details

NCT IDNCT02948660

SponsorXijing Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-06-30

View on ClinicalTrials.gov More Disorder of Consciousness trials