UnknownPhase 1/2

Collagen Membrane Combined With HUC-MSCs Transplantation in Patients With Nasal Septum Perforation

China12 participantsStarted 2016-11

Plain-language summary

The purpose of this study is to assess the safety and efficacy of collagen membrane combined with human clinical grade umbilical cord mesenchymal stem cells(HUC-MSCs) transplantation in patients with chronic nasal septum perforation.

Who can participate

Age range18 Years – 45 Years

SexALL

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Inclusion criteria

✓. Patients with nasal septum perforation area less than 1cm², and requires minimally-invasive treatment.
✓. Male or female, 18-45 years old.
✓. Ability and willingness to regular visit to hospital and follow up during the protocol Procedures.

Exclusion criteria

✕. Cystic fibrosis, immotile cilia syndrome and other genetic diseases.
✕. Syphilis, leprosy, tuberculosis and other specific infections.
✕. Severe Sinusitis.
✕. Autoimmune diseases or long term treatment with corticosteroids.
✕. Alzheimer's disease.
✕. Systemic diseases (e.g.,hypertension, diabetes and so on).
✕. Previous history of nasal cancer or after receiving radiotherapy.
✕. Drug abuse.

What they're measuring

The change of integrity of nasal septum assessed by endoscopic examination

Timeframe: baseline, 1,2,3,4,8,12 weeks after surgery

Trial details

NCT IDNCT02947191

SponsorChinese Academy of Sciences

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2021-12

View on ClinicalTrials.gov More Chronic Nasal Septum Perforation trials