Kinetics and Ecology of Human Papillomavirus Genital Infections in Young Women (NCT02946346) | Clinical Trial Compass
TerminatedNot Applicable
Kinetics and Ecology of Human Papillomavirus Genital Infections in Young Women
Stopped: Difficulty to continue follow-up during the coronavirus epidemic
France190 participantsStarted 2016-11-11
Plain-language summary
Most genital infections by human papillomaviruses (HPV) are asymptomatic or benign and clear within a few months or years. There infections are much less studies than chronic infections, even though they represent the main reservoir for the virus. The goal of this project is to decipher the kinetics of the virus and of the host immune response in acute HPV genital infections in your women. This will be performed by following women longitudinally and regularly in order to measure variations in virus load, immune cell count, cytokine concentration and antibody titers. The investigators will also investigate the interaction between these kinetics and host genetics and host vaginal microbiota
Who can participate
Age range
18 Years – 25 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Sexually active with at least one new partner over the last 12 months
* Subjects must be able and willing to give written informed consent
* Living in the 'agglomération de Montpellier'
Exclusion Criteria:
* History of cervical pathology
* Pregnant or intending to become pregnant soon (in the coming year)
* Infected by HIV
* Undergoing (or planning to undergo) heavy treatment (biotherapy, chemotherapy, immunosuppression)
* Participation in a clinical trial involving administration of drugswithin the last 4 weeks before the screening date
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Times series of HPV virus load in cervical smears measured by qPCR
Timeframe: from detection to clearance or persistence (i.e. 3 to 24 months)