CompletedNot Applicable

Neural Mechanisms for Appetitive Responses to High Reward Foods

United States114 participantsStarted 2016-02

Plain-language summary

This study is aimed at understanding neuroendocrine responses to different types of sugars and how this influences feeding behavior among lean, overweight, and obese individuals.

Who can participate

Age range18 Years – 35 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18-35 years, right-handed, weight change \<2% for at least 3 months prior to participation, no history of diabetes or other significant medical problems, fasting glucose \<126 mg/dl. * Lean group: BMI of 19-24.9 kg/m2 * Obese Group: BMI 30-40 kg/m2 * Overweight Group: BMI of 25-29.9 kg/m2 Exclusion Criteria: * Neurological, psychiatric or addiction disorder, fasting glucose ≥126 mg/dl, use of prescription medication (with the exception of contraceptives), tobacco use, contraindications to MRI scanning (detailed in Protection of Human Subjects), fructose intolerance, history of eating disorder, actively trying to lose weight.

What they're measuring

Changes of Blood oxygen level-dependent (BOLD) signal responses to food vs non-food cues after ingestion of different types of sugar. BOLD signal responses to food cues will be compared at the level of whole brain and within a priori regions of interest.

Timeframe: Sessions 1, 2, 3, 4

Cerebral Blood Flow Response

Timeframe: Sessions 1, 2, 3, 4

Systemic Metabolite and Hormone Responses

Timeframe: Sessions 1, 2, 3, 4

Trial details

NCT IDNCT02945475

SponsorUniversity of Southern California

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2020-03-13

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