Cystatin-C C-guided Vancomycin Dosing in Critically Ill Patients: A Quality Improvement Project

Inclusion Criteria: * Hospitalized in one of three intensive care units at Mayo Clinic in Rochester, Minnesota * Suspected or documented gram-positive infection * Prescribed IV vancomycin at a consistent dose and scheduled with 8, 12, or 24 hour Vancomycin dosing interval Exclusion Criteria: * Vulnerable population * Received greater than 1 dose of Vancomycin in the 96 hours before ICU admission * Baseline glomerular filtration rate (GFR) of less than 20 milliliters/minute * Undergoing renal replacement therapy * Body mass index \> 40kg/m2 * Weight \< 40kg