TerminatedNot Applicable

Human Mesenchymal Stem Cells in the Synovial Fluid of the Hip

Stopped: Study staff was unable to collect proper samples to meet study goals

United States20 participantsStarted 2016-09

Plain-language summary

Previous studies have shown an increase in the concentration of mesenchymal stem cells (MSC's) in the setting of osteoarthritis of the knee and its correlation to severity. Researchers have shown that as there is an increase in the severity of the disease, the concentration of stem cells also increases. The purpose of this study is to determine if there is the same increase in stem cell concentration in patients with osteonecrosis (ON) of the femoral head.

Who can participate

Age range18 Years – 90 Years

SexALL

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Inclusion Criteria: * Patients consented to undergo a THA (post-collapse osteonecrosis), hip arthroscopy or minimally invasive core decompression * Preoperative radiographic diagnosis of ON or FAI (femoral/acetabular impingement) Exclusion Criteria: * Pregnant females * Active infection, HIV, Hepatitis C or B, syphilis Immunodeficiency * Patients receiving hematopoetic growth factors or anti-angiogenesis products

What they're measuring

The quantity of mesenchymal stem cells present in the synovial fluid of patients with precollapse ON of the femoral head and postcollapse ON of the femoral head compared to patients without intraarticular hip pathology.

Timeframe: 24 months

Trial details

NCT IDNCT02941666

SponsorMayo Clinic

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-05

View on ClinicalTrials.gov More Osteonecrosis trials