Migraine Prophylaxis With Clopidogrel Trial

Inclusion Criteria: * migraine with or without aura diagnosed by a neurologist according to the criteria of the International Headache Society (3nd edition) * experience a minimum of two migraine attacks per month in a 3-month baseline phase * without regular use of prophylactic treatments or unresponsive to two and more commonly applied preventive medications * the presence of RLS confirmed by contrast-enhanced transcranial Doppler * no positive findings in cranial CT and MRI Exclusion Criteria: * other types of headaches * systemic chronic diseases, cerebrovascular disease, abnormal platelet or liver function * history of head injury * other contraindications to clopidogrel treatment