Mindfulness Based Stress Reduction for Older Adults With HIV Associated Neurocognitive Disorders

Inclusion Criteria: * Age ≥ 55 years * HIV-infected. For cases in which a participant has an undetectable plasma viral load and is not currently on cART, the participant will be asked to complete HIV antibody testing. * Undetectable plasma viral load * Symptomatic and sufficient neuropsychological testing abnormality to be rated as having impairment by consensus conference, but deficits in everyday functioning that would rate them as having no more than moderate disease. Participants with severe deficits consistent with dementia will not be randomized unless the study team agrees that deficits are mild enough to withstand rigors of MBSR. Exclusion Criteria: * Age \< 55 years * Failure to attend screening visits after two attempts and despite support offered * Unwilling to participate in 8-week intervention * Endorsing illicit drug use in the past 6 months * Current or extensive previous mindfulness practitioner * Detectable plasma HIV RNA (VL) in the previous 6 months or at enrollment. Individuals with VL \<500 copies will be allowed to enroll if they have a history of UD VL with unchanged cART and show documentation of their past two clinical VL at UD levels (so called "viral blips"). * Any treatable condition that may impact cognition, including: * Neurosyphilis (cases with serum RPR positive will undergo lumbar puncture to evaluate) * Thyroid disorders (untreated) * B12 deficiency (untreated) * Cancer (requiring chemotherapy) * Neurological or psychiatric con…