Effects of Glucocorticoids on Craving During Detoxification Treatment of Heroin and/or Stimulants

Inclusion Criteria: * Informed Consent as documented by signature, * age ≥18, * Group A Detoxification of stimulants (cocaine, amphetamine and/or methamphetamine); ICD-10: F14.2 and/or F15.2) OR Stable opioid dependency (no parallel consumption). Detoxifica-tion of stimulants. * Group B Opioid dependency and dependency of stimulants (cocaine, amphetamine and/or methamphetamine) and Detoxification of parallel consumption of stimulants and heroin (ICD-10: F11.2, 14.2, 15.2) * admission for detoxification to ward U2 of the University Psychiatric Hospital of Basel Exclusion Criteria: * contraindications to the class of drugs under study or to any of the excipients, e.g. known hypersensitivity or allergy to class of drugs or the investigational product; * acute or severe co-morbid psychiatric disturbances (such as a heavy episode of major depression with suicidal ideations, acute exacerbation of a bipolar disorder, acute exacerbation of schizophrenia, alcohol addiction with an acute relapse, psychosis, dementia); * current medical conditions excluding participation (such as acute infectious disease, moni-tored by elevated CRP, diabetes mellitus, anticoagulation therapy); * recent history of systemic or topic glucocorticoid therapy; * alcohol intake \> 0.0 ‰ according to breathalyser test on day 0 (screening) to exclude severe alcohol abuse; * specific drugs not allowed during the study or for specific periods of time prior to the administration of the test dose: Anticoagul…