WithdrawnNot Applicable

Changes in Central Arterial Pressure When Comparing ACOG Hypertensive Urgency Protocols

Stopped: PI withdrew the protocol

0Started 2016-08

Plain-language summary

The investigators plan to monitor the central blood pressure in women with severely elevated blood pressures (160/110) in pregnancy in the acute setting. Currently ACOG recommends 3 different options for blood pressure control, however no one has studied how these medications affect the central pressures, only peripheral blood pressure.

Who can participate

Age range

14 Years – 50 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Pregnant women * Singleton pregnancy * Severe hypertension as defined by a blood pressure of 160/110 with plans to treat Exclusion Criteria: * Multiple pregnancy * Blood pressures \< 160/110, or those whose blood pressures do not require medication for control * Irregular heart rhythms or arrhythmias * Peripheral arterial disease, leg artery disease * Reynaud's phenomena * Intense cold/hypothermia * If there is a wound at location of where central arterial cuff would be placed or tonometer for carotid assessment * Known sensitivity to labetalol, nifedipine, or hydralazine * Severe tachycardia (\>120) * Greater than 1st degree heart block * Severe asthma * Congestive heart failure or heart disease * Lupus * Inability to adequately monitor BP * Inability to monitor fetus (if 23 weeks or above) * Magnesium started prior to initiation of study

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

medication recommended by ACOG for severe hypertension

Timeframe: 20min from time of first normal blood pressure after intervention

Trial details

NCT IDNCT02933593

SponsorSt. Louis University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-01

View on ClinicalTrials.gov More Hypertension trials