CompletedNot Applicable

Quadriceps Exercise Before Total Knee Arthroplasty (The QUADX-1 Trial)

Denmark140 participantsStarted 2016-10

Plain-language summary

The trial investigates the efficacy of knee-extension exercise prior to total knee replacement. The participants are randomly allocated to one of three exercise dosages. There is no control group.

Who can participate

Age range

50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient is a possible candidate for a primary TKA due to knee osteoarthritis * Patient is eligible for home-based quadriceps exercise * Patient has an age ≥ 50 years * Patient is a possible candidate for primary unilateral TKA, based on all the below terms: * Knee pain \>3 (Numeric Rating Scale) in the last week * Kellgren-Lawrence classification grade ≥2 * Oxford Knee Score \<30 * Patient is resident in one of the three municipalities (København, Hvidovre or Brøndby) involved in the trial * Patient is able to speak and understand Danish Exclusion Criteria: * Exercise is contra-indicated for the patient * Patient has a neurological disorder * Patient has a diagnosed systemic disease (ASA score ≥ 3) * Patients with terminal illness * Patient has severe bone deformity demanding use of nonstandard implants * Weekly alcohol consumption above national recommendations (\>7 units women, \>14 units men)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Isometric knee-extension strength at 60 degrees knee flexion measured as Nm/kg body mass

Timeframe: Change from 1) baseline to 2) after 12 weeks of exercise/just before surgery

Trial details

NCT IDNCT02931058

SponsorHvidovre University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2020-02

View on ClinicalTrials.gov More Osteoarthritis, Knee trials

Who can participate

Age range

50 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.