Quadriceps Exercise Before Total Knee Arthroplasty (The QUADX-1 Trial) (NCT02931058) | Clinical Trial Compass
CompletedNot Applicable
Quadriceps Exercise Before Total Knee Arthroplasty (The QUADX-1 Trial)
Denmark140 participantsStarted 2016-10
Plain-language summary
The trial investigates the efficacy of knee-extension exercise prior to total knee replacement. The participants are randomly allocated to one of three exercise dosages. There is no control group.
Who can participate
Age range50 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patient is a possible candidate for a primary TKA due to knee osteoarthritis
* Patient is eligible for home-based quadriceps exercise
* Patient has an age ≥ 50 years
* Patient is a possible candidate for primary unilateral TKA, based on all the below terms:
* Knee pain \>3 (Numeric Rating Scale) in the last week
* Kellgren-Lawrence classification grade ≥2
* Oxford Knee Score \<30
* Patient is resident in one of the three municipalities (København, Hvidovre or Brøndby) involved in the trial
* Patient is able to speak and understand Danish
Exclusion Criteria:
* Exercise is contra-indicated for the patient
* Patient has a neurological disorder
* Patient has a diagnosed systemic disease (ASA score ≥ 3)
* Patients with terminal illness
* Patient has severe bone deformity demanding use of nonstandard implants
* Weekly alcohol consumption above national recommendations (\>7 units women, \>14 units men)
What they're measuring
1
Isometric knee-extension strength at 60 degrees knee flexion measured as Nm/kg body mass
Timeframe: Change from 1) baseline to 2) after 12 weeks of exercise/just before surgery