In this investigation the investigators utilized N-acetylcysteine (NAC) supplementation to enhance reduced glutathione (GSH) stores during an 8-day recovery period from a strenuous eccentric exercise protocol in order to test the hypotheses: i) redox status perturbations in skeletal muscle are pivotal for the immune responses and ii) antioxidant supplementation may alter immune cell responses following exercise-induced muscle microtrauma.
Age range
18 Years – 30 Years
Sex
MALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Changes in protein carbonyls in red blood cells
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in thiobarbituric acid reactive substances in red blood cells
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in total antioxidant capacity in serum
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in reduced glutathione in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in oxidized glutathione in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in catalase activity in red blood cells
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in creatine kinase activity in serum
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in high sensitivity C-reactive protein in serum
Timeframe: Pre-exercise, 2 hours post-exercise, 1 day post-exercise, 2 days post-exercise, 3 days post-exercise
Changes in white blood cell count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in adhesion molecule concentration in blood
Timeframe: Pre-exercise, 2 hours post-exercise, 1 day post-exercise, 2 days post-exercise, 3 days post-exercise
Changes in cytokine concentration in serum
Timeframe: Pre-exercise, 2 hours post-exercise, 1 day post-exercise, 2 days post-exercise, 3 days post-exercise, 8 days post-exercise
Changes in neutrophil count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in lymphocyte count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in monocyte count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in basophil count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in eosinophil count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in T-helper cell count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in T cytotoxic cell count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in natural killer-T (NK-T) cell count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in 62L macrophage count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in B lympho cell count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in natural killer (NK) cell count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in macrophage count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in HLA+/Macr+ macrophage count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise
Changes in 11B+ macrophage count in blood
Timeframe: Pre-exercise, 2 hours post-exercise, daily for 8 consecutive days post-exercise