Atropine in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
United States6 participantsStarted 2016-10
Plain-language summary
To test the hypothesis that increasing the sinus node rate with atropine treatment prior to exercise will reduce exercise-triggered ventricular ectopy compared to baseline in patients with CPVT.
Who can participate
Age range6 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age \>/= 6 years
* Able to provide written informed consent
* Clinical diagnosis of CPVT
* Able to exercise on a treadmill
* Successful completion of a minimum of 2 exercise stress tests without adverse events
Exclusion Criteria:
* Contraindication to treadmill stress testing according to Vanderbilt University Medical Center's clinical protocols (unstable angina, decompensated congestive heart failure, severe hypertension (≥ 170/90 mmHg), acute myocardial infarction (\<4 days), moderate to severe aortic stenosis, acute pulmonary embolism, severe pulmonary hypertension, outflow tract obstruction, hypertrophic cardiomyopathy, left main coronary stenosis, left bundle branch block)
* Females who are pregnant
* In the judgement of the investigator, any clinically significant ongoing medical or surgical condition that might jeopardize the subject's safety or interfere with the conduct of the study
What they're measuring
1
Number of Ventricular Ectopic Beats Recorded During Exercise (and Recovery)