CompletedPhase 4

IV Antibiotics With Lavage for Severe PD Peritonitis

Hong Kong46 participantsStarted 2014-03

Plain-language summary

This is a randomized controlled trial to evaluate whether a switch to intravenous antibiotics with adjunctive lavage can improve the outcome of severe peritoneal dialysis related peritonitis.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Prevalent PD patients with age \>= 18 years old suffering from PD peritonitis * PD effluent white cell count \>1090/mm2 on peritonitis day 3 * Lack of clinical response * Informed consent available Exclusion Criteria: * PD peritonitis in association with exit site or tunnel infection * Relapsing peritonitis (i.e. peritonitis caused by same organism within 4 weeks after completion of antibiotics therapy) * Fungal peritonitis * Mycobacterial peritonitis (both tuberculosis and non-tuberculosis species) * Clinical suspicion of surgical peritonitis * Penicillin- or cephalosporin allergy, that cefazolin and ceftazidime could not be used

What they're measuring

Peritoneal dialysate effluent (PDE) white cell count and bacterial culture

Timeframe: PDE is monitored every 48 hours, until white cell count <100/mm3 and bacterial culture is negative; assessed up to 3 weeks

Number of participants requiring Tenckhoff catheter removal

Timeframe: Tenckhoff catheter removal is arranged when there is no clinical response after 5 days of treatment

Trial details

NCT IDNCT02926846

SponsorAlice Ho Miu Ling Nethersole Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-11

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