CompletedNot Applicable

Imaging Silent Brain Infarct And Thrombosis in Acute Myocardial Infarction

Spain92 participantsStarted 2016-09

Plain-language summary

This project aims to assess the ability of cardiac imaging (cardiac MRI and Doppler-echocardiography) post-processing tools to predict a combined end-point of intraventricular thrombosis, silent brain infarcts, clinical stroke and peripheral arterial embolism in patients with first acute myocardial infarction and ventricular dysfunction.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. First ST elevation AMI undergoing (or not) revascularization.
✓. Sinus rhythm in the first 24 hours of the AMI.
✓. Written informed consent. ( 4) Left ventricular ejection fraction \< 45% measured by echocardiography in the first 24-72 hours after AMI symptoms onset.

Exclusion criteria

✕. Implantable defibrillation or stimulation devices not compatible with MRI.
✕. Killip-IV class or other shock situations or marked peripheral hypoperfusion.
✕. Aborted sudden death or other causes of possible acute brain damage attributed to cerebral hypoperfusion.
✕. Hemodynamically significant valvular disease or prosthetic heart valves.
✕. Claustrophobia that impedes MRI scanning.
✕. Atrial fibrillation (AF) in the first 24 hours after AMI.
✕. Carotid Artery Disease diagnosed with stenosis greater than 50%.
✕. Full oral anticoagulation prior to admission or indication of anticoagulation.

What they're measuring

Combined binary variable consisting of one of the following: ventricular thrombosis assessed by cardiac MRI, silent brain infarct detected by brain MRI, peripheral acute arterial embolism or ischemic stroke within the 6 months after a first STEMI

Timeframe: 6 months

Trial details

NCT IDNCT02917213

SponsorHospital General Universitario Gregorio Marañon

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2022-01-01

View on ClinicalTrials.gov More Myocardial Infarction trials