Effects of Botanical Microglia Modulators in Gulf War Illness (NCT02909686) | Clinical Trial Compass
CompletedNot Applicable
Effects of Botanical Microglia Modulators in Gulf War Illness
United States36 participantsStarted 2016-07
Plain-language summary
The overall objective of this protocol is to test if Gulf War Illness (GWI) involves chronic inflammation that cannot be measured with typical techniques. The investigators will be observing the effects of nine different botanical compounds (supplements) that are known to suppress inflammation. If one of those supplements helps the symptoms of GWI, it will give the investigators information about what is wrong in people with GWI.
Who can participate
Age range
39 Years – 65 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Male
. Age 39-65, inclusive
. Veterans who meet the Kansas inclusion criteria for GWI
. Present in Persian Gulf between 1990 and August 1991
. Patient completes daily report during 2 week baseline period (at least 80% completion rate)
. Able to receive a venous blood draw
Exclusion criteria
. Positive rheumatoid factor at screening
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial studied 'botanical microglia modulators' for Gulf War Illness — can you explain what those are, and whether any of the specific botanicals tested showed a meaningful change in overall disease severity compared to where participants started?
2Since this trial has already been completed, has the results data been published anywhere, and what did it find about whether these botanical treatments actually helped reduce Gulf War Illness symptoms?
3Gulf War Illness can involve such a wide range of symptoms — how did this trial define and measure 'overall disease severity,' and do you think that measurement reflects the specific symptoms I'm struggling with most?
4This trial was listed as Phase NA, which sometimes applies to studies that aren't testing a new drug in the traditional sense — does that affect how much we can trust the safety and effectiveness data from it, and would you consider these botanical approaches evidence-based enough to try?
5Given that this trial is now completed, are there any follow-up studies or current treatment approaches building on what was learned here that might be worth exploring as options for me?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change From Baseline in Overall Gulf War Illness Disease Severity