CompletedNot Applicable

Effects of Botanical Microglia Modulators in Gulf War Illness

United States36 participantsStarted 2016-07

Plain-language summary

The overall objective of this protocol is to test if Gulf War Illness (GWI) involves chronic inflammation that cannot be measured with typical techniques. The investigators will be observing the effects of nine different botanical compounds (supplements) that are known to suppress inflammation. If one of those supplements helps the symptoms of GWI, it will give the investigators information about what is wrong in people with GWI.

Who can participate

Age range39 Years – 65 Years

SexMALE

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Inclusion criteria

✓. Male
✓. Age 39-65, inclusive
✓. Veterans who meet the Kansas inclusion criteria for GWI
✓. Present in Persian Gulf between 1990 and August 1991
✓. Patient completes daily report during 2 week baseline period (at least 80% completion rate)
✓. Able to receive a venous blood draw

Exclusion criteria

✕. Positive rheumatoid factor at screening
✕. Positive anti-nuclear antibody at screening
✕. C-reactive protein\> 3mg/L at screening
✕. Erythrocyte Sedimentation Rate\> 40mm/hr at screening
✕. Auto-immune disorder
✕. Diagnosed Rheumatologic Condition
✕. Major PTSD symptoms
✕. Hypotension (under 90/60 mm Hg) or history of cardiovascular disease

What they're measuring

Change From Baseline in Overall Gulf War Illness Disease Severity

Timeframe: Week 17

Trial details

NCT IDNCT02909686

SponsorUniversity of Alabama at Birmingham

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-09

Results submitted2024-04-04

View on ClinicalTrials.gov More Gulf War Illness trials