Extracellular RNA Markers of Liver Disease and Cancer (NCT02908048) | Clinical Trial Compass
TerminatedNot Applicable
Extracellular RNA Markers of Liver Disease and Cancer
Stopped: Ran out of funds
United States1,865 participantsStarted 2014-07
Plain-language summary
The study will examine and evaluate the use of extracellular RNA in blood as markers for the diagnosis of liver disease or cancer, and as markers for prediction of response to treatment or recurrence of cancer after surgery
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Lab results from within the previous 90 days.
* Diagnosis of HCC or biliary tract cancer
* Diagnosis of cirrhosis based on histology, imaging, or ultrasound.
* Diagnosis of a chronic liver disease without cirrhosis.
Exclusion Criteria for the HCC/biliary tract cancer group:
* Prior solid organ transplant.
* Previous cancer history with the last 5 years (excluding non-melanoma skin cancer), participation in a treatment trial for HCC
Exclusion criteria for the cirrhosis and chronic liver disease groups:
* Prior solid organ transplant.
* Previous or current cancer history within the past 5 years (excluding non-melanoma skin cancer).
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Since this trial has been terminated early, can you tell me why it was stopped and whether any of the findings from it might still be relevant to my diagnosis or care?
2This study was looking at extracellular RNA markers in blood as a way to detect liver cancer — is there any similar research or test currently available that my care team uses, or that I should know about?
3Given that this trial focused on people with hepatocellular carcinoma, biliary tract cancer, and cirrhosis, how does my specific diagnosis fit into that picture, and are there other active studies looking at early detection markers that might be worth exploring?
4Since this was an observational study measuring tumor markers and imaging rather than testing a treatment, does participating in research like this actually change anything about my treatment plan, or is it purely for data collection?
5Are there currently any other active clinical trials or standard diagnostic approaches for my condition that you'd recommend we look at, given that this particular study is no longer enrolling?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Diagnosis of liver cancer based on tumor markers and imaging studies.