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A Case Control Study to Identify the Role of Epigenetic Regulation of Genes Responsible for Energy Metabolism and Mitochondrial Function in the Obesity Paradox in Cardiac Surgery

United Kingdom80 participantsStarted 2016-09-09

Plain-language summary

This is a prospective, single-centre case control comparison of expression of target genes responsible for energy utilisation, mitochondrial function and oxidative stress and levels of histone acetylation/ DNA methylation in obese and non-obese adult cardiac surgery patients. The study aims to test several inter-related hypotheses in a consecutive sequence of patients undergoing coronary artery bypass grafting.

Who can participate

Age range16 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients with pre-existing paroxysmal, persistent or chronic atrial fibrillation, Exclusion Criteria: * Patients with pre-existing inflammatory state: sepsis undergoing treatment, acute kidney injury within 5 days, chronic inflammatory disease, congestive heart failure. * Emergency or salvage procedure. * Ejection fraction \<30 %. * Patient in a critical preoperative state (Kidney Disease: Improving Global Outcomes (KDIGO) Stage 3 AKI \[20\] or requiring inotropes, ventilation or intra-aortic balloon pump). * Pregnancy.

What they're measuring

Post surgery inotrope score

Timeframe: inotrope score measured up to 48 hours post-surgery

Trial details

NCT IDNCT02908009

SponsorUniversity of Leicester

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-10-07

Contact for this trial

Tracy Kumar

01162583039 tk98@leicester.ac.uk

View on ClinicalTrials.gov More C.Surgical Procedure; Cardiac trials