CompletedNot Applicable

The Effects of Visible Light on the Skin After Administration of Oral Polypodium Leucotomos

United States22 participantsStarted 2015-07-01

Plain-language summary

Polypodium Leucotomos Extract (PLE) is a tropical fern that has antioxidative, photoprotective, chemoprotective, anti-inflammatory, and immunomodulatory properties. The antioxidative effects of PL include inhibition and scavenging of free radicals, lipid peroxidation and reactive oxygen species (ROS) such hydrogen peroxide, superoxide anion, hydroxyl radical and singlet oxygen. Visible light (400-700 nm) causes pigmentation in melanocompetent individuals and induces DNA damage in the human skin through ROS production. The goal of this study is to determine whether the administration of oral PLE has an effect on the development of visible light induced pigmentation.

Who can participate

Age range18 Years – 100 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patient age 18 and older * Patients Fitzpatrick III-VI * Patient able to understand requirements of the study and risks involved * Patient able to sign a consent form Exclusion Criteria: * A recent history of vitiligo, melasma, and other disorders of pigmentation with the exception of post inflammatory hyperpigmentation * A known history of photosensitivity disorders * A known history of melanoma or non-melanoma skin cancers * Those planning on going to the tanning parlors * Using any of the photosensitizing medication * A woman who is lactating, pregnant, or planning to become pregnant * Patient planning on exposing the irradiated or control areas to the sun

What they're measuring

Difference in pigmentation pre and post administration of oral PLE

Timeframe: 42 days

Trial details

NCT IDNCT02904798

SponsorHenry Ford Health System

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2017-02-14