HCV Treatment Immune Response With Grazoprevir/Elbasvir Before or After Renal Transplant

Inclusion Criteria: * At least 18 years of age at the time of screening * Have stable renal function for one month (30 days) prior to enrollment * Have Chronic HCV infection prior to transplantation with documented HCV viremia ≥ 1,000 IU/ml at screening and either documented HCV Ab positivity or HCV viremia ≥ 1,000 IU/ml at least 6 months prior to enrollment. * Documented genotype 1 HCV infection prior to enrollment and after their transplant in the post-transplantation cohort * HCV disease staging within 12 months prior to enrollment by liver biopsy, transient elastography, or biochemical testing * Be able to give informed consent and comply with study guidelines * Women of childbearing age will be required to have a negative pregnancy test at enrollment and use birth control throughout the duration of treatment. Inclusion Criteria Specific to the Pre-transplant Arm Patients will either be: * On the transplant waiting list followed by the University of Maryland's nephrology clinic or the Baltimore VA's nephrology clinic * On chronic hemodialysis not yet on the transplant list and followed in the University's hemodialysis center or in the University's nephrology clinic * Have chronic kidney disease with GFR \<50 Inclusion Criteria Specific to the Post-transplant Arm • Patients will have undergone renal transplantation no greater than five years prior to enrollment and will be followed in our University's nephrology and infectious disease clinic. They will all have stabl…