Early Detection of Chorioamnionitis in Preterm Premature Rupture of Membranes

Inclusion Criteria: * pPROM between 26 to 34 WG clinically proven or confirmed by a positive IGBP-1 protein test in a vaginal sample * 18 years old or older * singleton pregnancy Exclusion Criteria: * multiple pregnancy * intra-uterine growth restriction defined by a fetal weight under the 10th percentile (AUDIPOG) * active smoking * gestational diabetes or pre-existing diabetes mellitus * maternal pathology : * congenital or acquired heart defect * pulmonary embolism in progress or under treatment * pulmonary hypertension * renal insufficiency * Chronic obstructive pulmonary disease * systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome * heart, neurological or genetic fetal proven malformations