Clinical and experimental data suggest that neutrophil activation and extravasation are deleterious in acute ischemic stroke (AIS) involving an increased risk of unfavorable outcome and hemorrhagic transformation (HT). However, clinical trials targeting neutrophil recruitment in AIS patients were negative. Recently, an experimental study has shown that neutrophil activation and transmigration begin immediately after the occlusion. Inhibition of neutrophil recruitment several hours after the start of ischemia appears therefore too late to have a clinical relevance. The objective is to study the time dependent impact of neutrophils in AIS and the predominant mediators in each time point to identify the appropriate therapeutic target and time window.
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
neutrophil counts
Timeframe: before recanalization
neutrophil counts
Timeframe: immediately after recanalization
neutrophil counts
Timeframe: 24 hours after recanalization
neutrophil protease counts
Timeframe: before recanalization
recanalization score
Timeframe: immediately after endovascular procedure
acute ischemic stroke etiology
Timeframe: within 24 hours after endovascular procedure
severity of neurologic symptoms
Timeframe: baseline
disruption of the blood-brain-barrier
Timeframe: within 24 hours after endovascular procedure
brain haemorrhage
Timeframe: 24 hours after endovascular procedure
Recovery of motor function after stroke
Timeframe: 3 months
mortality
Timeframe: 3 months
adhesion molecules counts
Timeframe: before recanalization
adhesion molecules counts
Timeframe: immediately after recanalization
adhesion molecules counts
Timeframe: 24 hours after recanalization
free plasma DNA counts
Timeframe: before recanalization
free plasma DNA counts
Timeframe: immediately after recanalization
free plasma DNA counts
Timeframe: 24 hours after recanalization
neutrophil protease counts
Timeframe: immediately after recanalization
neutrophil protease counts
Timeframe: 24 hours after recanalization