Neurophysiological Correlates of Cognitive Tasks in Healthy Volunteers -WP3 P003 (NCT02899403) | Clinical Trial Compass
TerminatedNot Applicable
Neurophysiological Correlates of Cognitive Tasks in Healthy Volunteers -WP3 P003
Stopped: sponsor decision COVID
France6 participantsStarted 2017-05-19
Plain-language summary
In the perspective to better evaluate the efficacy of new treatment strategies for Alzheimer disease (AD), it appears important to develop experimental paradigms to precisely measure cognitive endpoints/biomarkers that may be used in healthy volunteers as tools to validate drug efficacy profile.
The use of Electroencephalography (EEG) may be, therefore, a good candidate. The purpose of the present study is to use EEG to more precisely explore cognitive processes in healthy subjects, with a particular interest in episodic and working memory functions that are usually altered in both AD and Mild Cognitive Impairment (MCI) as well as to better understand underlying neural mechanisms involved in these processes.
Who can participate
Age range
18 Years – 30 Years
Sex
MALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Right-handed
* In good health on the basis of the medical interview (medical history, symptoms), the physical examination and vital signs
* Non smoker and with no history of drug or alcohol abuse
* Without chronic treatment
* With normal hearing and normal vision including color (with correction)
* French speaker and able to understand the test instructions
* Has provided written informed consent
* Able to read and understand the Information Form and comply with the protocol instructions and restrictions
Exclusion Criteria:
* Cognitive impairment (MoCA \< 26)
* Cognitive complaint (MacNair Scale \> 15)
* History of brain disease (severe brain trauma, stroke, cerebral tumor…) or current cerebral disease
* Major medical or surgical history
* Current chronic disease
* Vascular or metabolic risk factor
* History or current mental disease or addiction (MINI)
* Family history of young onset dementia
* Family history of chronic or severe neurological or mental disease (first degree relatives)
* In the opinion of the investigator, is unlikely to comply with the study protocol or is unsuitable for any other reason
* Participates to another clinical trial or is still being within a washout period of a previous clinical trial
* Already exposed to cognitive tests used in this study.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
EEG spectral power during RVIP task as compared to resting state
Timeframe: within 7 days after inclusion ( session1)