This is a pilot imaging study to determine whether molecular imaging with 18\^F fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT), 11\^C-Methionine (MET) PET/CT, and salivary gland magnetic resonance imaging (MRI) with Dotarem (gadoterate meglumine) have the potential to characterize and quantify disease manifestations in primary Sjögren's syndrome (pSS) subjects. This will be achieved by assessing the associations and consistency between the imaging techniques studied, clinical assessments (salivary and tear flow and clinical scores), laboratory biomarkers, and histological findings on minor salivary gland biopsy. In this study, healthy volunteers will be enrolled in Group A and pSS subjects in Group B. The subjects will be required to undergo screening and baseline assessments including unstimulated and stimulated salivary flow and Schirmer's test; an imaging visit (Visit 1); a sample collection visit (Visit 2) for repeat of selected baseline assessments and a minor salivary gland biopsy for pSS subjects only; and a follow-up visit. The total duration of participation in the study will be up to 11 weeks.
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Standardized Uptake Value (SUV) for 18F-FDG for pSS Participants in Selected Body Areas
Timeframe: Visit 1: Within 6 weeks after Baseline
SUV of Lachrymal Gland, Parotid Gland, and Submandibular Gland for 18F-FDG for pSS Participants
Timeframe: Visit 1: Within 6 weeks after Baseline
Tissue to Reference (TR) Ratio for 18F- FDG for pSS Participants
Timeframe: Visit 1: Within 6 weeks after Baseline
TR Ratio of Lachrymal Gland, Parotid Gland, and Submandibular Gland for 18F-FDG for pSS Participants
Timeframe: Visit 1: Within 6 weeks after Baseline
Total Inflammatory Volume for 18F- FDG for pSS Participants at Selected Body Areas
Timeframe: Visit 1: Within 6 weeks after Baseline
SUV for 11C- MET in Selected Body Areas
Timeframe: Visit 1: Within 6 weeks after Baseline
SUV of Lachrymal Gland, Parotid Gland, and Submandibular Gland for 11C-MET
Timeframe: Visit 1: Within 6 weeks after Baseline
TR Ratio for 11C- MET
Timeframe: Visit 1: Within 6 weeks after Baseline
TR Ratio for 11C- MET of Salivary Glands, Lachrymal Gland, Parotid Gland, and Submandibular Gland
Timeframe: Visit 1: Within 6 weeks after Baseline
Total Inflammatory Volume 11C- MET at Selected Body Areas
Timeframe: Visit 1: Within 6 weeks after Baseline
Multi-parametric MRI Derived Parameter: Apparent Diffusion Coefficient (ADC)
Timeframe: Visit 1: Within 6 weeks after Baseline
Multi-parametric MRI Derived Parameter: Pure Diffusion Coefficient (D)
Timeframe: Visit 1: Within 6 weeks after Baseline
Multi-parametric MRI Derived Parameter: Microvascular Volume Fraction
Timeframe: Visit 1: Within 6 weeks after Baseline
Multi-parametric MRI Derived Parameter: Exchange Rate (KTrans)
Timeframe: Visit 1: Within 6 weeks after Baseline