CompletedPhase 4

Impact of 30 mg/kg Amikacin and 8 mg/kg Gentamicin on Serum Concentrations in Critically Ill Patients With Severe Sepsis

63 participantsStarted 2014-10

Plain-language summary

Low first-dose peak serum concentrations of amikacin and gentamicin are commonly reported in ICU patients. The present study aimed to assess whether 30 mg/kg amikacin or 8 mg/kg gentamicin achieved target concentrations in ICU patients with severe sepsis.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * ICU patient with severe sepsis * Treated with aminoglycosides Exclusion Criteria: * Renal replacement therapy * Allergy to aminoglycosides * Confirmed and/or suspected to have myasthenia * ICU-acquired neuromuscular disorder * Under guardianship * Prisoners * The patient has already participated in the present protocol

What they're measuring

Presence/absence of target peak serum concentration of aminosides

Timeframe: 30 minutes after the end of the infusion.

Trial details

NCT IDNCT02898961

SponsorCentre Hospitalier Universitaire de Nīmes

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-12-31

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