Clinical Benefit of Spa Care on Severe Radiation-induced Fibrosis After Postoperative Radiotherapy for Breast Cancer

Inclusion Criteria: * women * age ≥ 18 and \<80 years old * invasive or in situ breast carcinoma * non-metastatic disease. * postoperative radiotherapy completed since at least 6 months * unilateral breast radiotherapy * grade \> 2 dermal and/or soft tissue toxicity (CTCAE v4.0) * no inflammatory ou infectious flare on the breast at the time of inclusion * ability to provide an informed written consent form * affiliation to a social security system Exclusion Criteria: * age \<18 or ≥ 80 years old * evolutive cancer * Metastatic Disease * Patient undergoing specific treatment for breast cancer (except adjuvant endocrine therapy and / or adjuvant Herceptin) at the time of inclusion * bilateral Breast/chest wall Radiotherapy * breast prosthesis bearer * Body Mass Index \> 40 or \<18.5 * chronic skin ulceration within the treated breast at the time of inclusion * contraindications to spa care : * inflammatory disease in flare at the time of inclusion * active infections * heart failure (NYHA class\> 1) * chronic respiratory failure * labile blood pressure * bullous dermatitis * evolutive chronic skin disease * hypersensitivity to pentoxifylline or any of the excipients * acute myocardial infarction * ongoing hemorrhage or major bleeding risk * use of oral anticoagulants * pregnant or likely to be in 6 months or breastfeeding * patients deprived of liberty or under supervision