Peri-implant Bone Changes in Post-menopausal Osteoporotic Women

Inclusion Criteria: * Participants must present a diagnosis of osteoporosis based on DXA measurement of the bone mineral density at the femur neck and/or total hip and/or lumbar spine (T value 2.5 SD or more below the young female adult mean) within the past 24 months. * Not in treatment with anti-resorptive agents (like bisphosphonates and denosumab) for more than 4 consecutive years, in order to reduce the risk of medication-related osteonecrosis of the jaws (Lo et al., 2010). * ≥ 50 years old. * In self-reported menopause, defined as the permanent cessation of ovulation, for at least one year (Soules et al., 2001). * Edentulous area involving a maximum of two teeth (wisdom teeth and second molars are excluded) and presenting at least one neighbouring tooth (e.g. gap in the area of a second premolar and first molar, with first premolar in place). * Residual alveolar width ≥ 4 mm (Milinkovic and Cordaro, 2014), residual alveolar height \>8 mm, enough inter-arch space for a crown (at least 5 mm) and a minimum distance of 7 mm from the adjacent teeth (Shah and Lum, 2008). The width and height will be confirmed after x-ray examination in Visit 2. * Possibility to restore a functional occlusion with a minimum of four occlusal units (i.e. pairs of occluding posterior teeth). * Willingness to replace the missing tooth/teeth with dental implants * Registration with a GDP Exclusion Criteria: * On chronic treatment (i.e., two weeks or more) with any medication severely affecting o…