CompletedPhase 4

Interest of a Tetanus Test at a Fixed Remifentanil Concentration Before Laryngoscopy and Skin Incision

48 participantsStarted 2013-01

Plain-language summary

Individually-tailored administration of the opioid analgesic component during general anaesthesia is still a challenge for the anesthesiologist. The aim of this protocol is to look if the gradient response of a nociception index to a calibrated tetanic stimulus during standard anesthetic conditions, could help to titrate remifentanil analgesia before tracheal intubation and before skin incision. The studied parameters are the SPI index developed by General Electric, the "Analgesia Nociception Index" and the pupil dilation using the pupil scan algometer.

Who can participate

Age range18 Years – 80 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age \>= 18 years * Informed consent obtained during the pre-anesthetic visit * American Society Anesthesiology status I or II * Scheduled surgery under general anesthesia, and necessitating endotracheal intubation and controlled mechanical ventilation * Body mass index (BMI) between 17 and 30 kg/m2 Exclusion Criteria: * Pregnancy * Patient refusal * Pace maker (all modes) * Heart failure * Ejection fraction \< 50% * Symptomatic aortic or mitral pathology * Non sinus rhythm * Chronic use of beta blocking agents or other anti-hypertensive medications, except for diuretics * Dysautonomia * Diabetes * Spontaneous ventilation during anesthesia * Allergy to one of the medications used during this experiment

What they're measuring

hemodynamic stability following tracheal intubation and surgical incision

Timeframe: within 60 minutes after anesthesia induction

Trial details

NCT IDNCT02884310

SponsorErasme University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-12