CompletedPhase 4

Real Time Myocardial Perfusion Echocardiography for Coronary Allograft Vasculopathy

United States36 participantsStarted 2016-09

Plain-language summary

Is real-time myocardial perfusion echocardiography (RTMPE) a feasible and effective non-invasive method to detect significant Coronary Allograft Vasculopathy in pediatric and adult cardiac transplant recipients? Will perfusion deficits correlate with significant coronary artery stenosis identified by standard stress echocardiography and Invasive Coronary Angiography (ICA), and identify diffuse small vessel disease more effectively than current non-invasive techniques?

Who can participate

Age range1 Year

SexALL

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Inclusion: * Cardiac transplant recipients (\> or equal to 10 months post transplant) * Clinically followed at Mayo Clinic, Rochester Minnesota Exclusion: * Standard contraindications to the use of ultrasound contrast and pharmacologic stress * Recent (\< 3 months) hospitalization for heart failure, acute coronary syndrome or allograft rejection * Multi-organ transplant Known or suspected right-to-left, bi-directional, or transient right-to-left cardiac shunts * Hypersensitivity to perflutren

What they're measuring

Number of Subjects With a Perfusion Defect

Timeframe: baseline

Trial details

NCT IDNCT02880137

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-06

Results submitted2019-05-27

View on ClinicalTrials.gov More Cardiac Allograft Vasculopathy trials