Safety and Effectiveness of VYC-12 Hyaluronic Acid Injectable Gel for Treatment of Superficial Cutaneous Depressions

Inclusion Criteria: * Participants in good general health * Score of 2=Moderate (coarse and uneven visual skin texture) or 3=Severe (coarse visual skin texture, crosshatched fine lines) on both cheeks using the 5-Point Allergan Skin Roughness Scale (ASRS). Exclusion Criteria: * Has undergone tissue augmentation with dermal fillers including HA, calcium hydroxylapatite, autologous fat, mesotherapy, or other cosmetic procedures (eg. face-lift, laser, photomodulation, intense pulsed light, radiofrequency, dermabrasion, chemical peel, or other ablative procedures) in the face or neck within the past 12 months * Has received any crosslinked HA filler in any anatomic area within the past 12 months * Has undergone treatment with botulinum toxins in the face or neck within the past 6 months * Has ever received semi-permanent fillers or permanent facial implants (eg. poly-L-lactic acid, polymethylmethacrylate, silicone, expanded polytetrafluoroethylene) anywhere in the face or neck * Has facial hair that would interfere with the visualization of the face or neck * Has undergone a dental procedure within the past 6 weeks * Has a tendency to develop hypertrophic scarring * Has a history of allergy to HA products and/or to gram-positive bacterial proteins as HA is produced by Streptococcus-type bacteria * Has a history of anaphylactic shock * Has been previously diagnosed with streptococcal disease (eg. recurrent sore throat, acute rheumatic fever) * Has current cutaneous inflammatory…